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Table 3 Maximal constriction and concentrations elicited half-maximal vasoconstriction to phenylephrine and insulin with L-NAME

From: Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

 

Phenylephrine

Insulin + L-NAME

60 mM KCl

Groups

Max, % EC50(× 10-7M)

Max, % EC50(× 10-6M)

Max, %

SD+V

9.5 ± 2.2

2.5 ± 0.5

5.8 ± 1.1

3.9 ± 2.2

12 ± 3.1

H+C

16 ± 2.2*

3.1 ± 0.6

6.8 ± 1.2*

0.011 ± 0.035*

13 ± 2.4

H+C

8.7 ± 2.1†

2.3 ± 0.4

6.2 ± 1.6

0.006 ± 0.009*

12 ± 1.2

H+R

11 ± 1.9†

11 ± 3*†

6.4 ± 0.8

6.3 ± 5.2†

13 ± 0.9

  1. Notes: SD+V: Vehicle treated Sprague-Dawley rats. H+V: Vehicle treated DH rats. H+C: Captopril treated DH rats. H+R: ruboxistaurin treated DH rats. * indicates statistical difference in comparison with SD+V (P < 0.05). † indicates statistical difference in comparison with H+V (P < 0.05).
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Cardiovascular Diabetology

ISSN: 1475-2840