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Table 2 Maximal vasorelaxations and concentrations elicited half-maximal vasorelaxation to acetylcholine (ACh), insulin, ACh with insulin, and sodium nitroprusside (SNP)

From: Protein Kinase C inhibition ameliorates functional endothelial insulin resistance and Vascular Smooth Muscle Cell hypersensitivity to insulin in diabetic hypertensive rats

 

Ach

Insulin

Ach + Insulin

SNP

Groups

Max, % IC50(× 10-7M)

Max, % IC 50(× 10-10M)

Max, % IC50(× 10-7M)

Max, % IC50(× 10-8M)

SD+V

116 ± 22

1.2 ± 0.8

17 ± 12

1.1 ± 1.2

116 ± 17

0.6 ± 0.5

103 ± 20

2.4 ± 1.7

H+V

67 ± 13*

1.3 ± 0.7

6 ± 7*

140+122*

98 ± 15

0.7 ± 0.6

83 ± 17

43 ± 3.1

H+C

65 ± 15*

1.8 ± 0.9

21 ± 10†

3.3 ± 3.8†

88 ± 13

1.3 ± 0.9

83 ± 16

1.7 ± 0.9

H+R

73 ± 14*

1.6 ± 0.9

22 ± 11†

1.5 ± 1.8†

98 ± 11

1.4 ± 0.9

88 ± 15

2.2 ± 1.2

  1. Notes: SD+V: Vehicle treated Sprague-Dawley rats. H+V: Vehicle treated DH rats. H+C: Captopril treated DH rats. H+R: ruboxistaurin treated DH rats. * indicates statistical difference in comparison with SD+V (P < 0.05). † indicates statistical difference in comparison with H+V (P < 0.05).