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Table 6 Estimated Relative Risk (Hazard Ratio) of Death from CVD Attributable to a 10 mg/dL Increase in Serum Non-HDL-C Concentration and a 10 mg/dL Increase in Serum LDL-C Concentration Among U.S. Adults Aged ≥ 20 Years with Diabetes, the Third National Health and Nutrition Examination Survey Linked Mortality Study, 1988-2006

From: Serum Non-high-density lipoprotein cholesterol concentration and risk of death from cardiovascular diseases among U.S. adults with diagnosed diabetes: the Third National Health and Nutrition Examination Survey linked mortality study

Cause of death

Non-HDL-C

LDL-C

Unadjusted risk estimates

  

   Total CVD

1.07 (0.97-1.18)

1.06 (0.95-1.19)

   Ischemic heart disease

1.14 (1.01-1.29)

1.14 (0.99-1.32)

   Stroke

1.09 (0.93-1.29)

1.08 (0.92-1.27)

   Other CVD

0.93 (0.82-1.04)

0.89 (0.78-1.01)

Adjusted risk estimatesa

  

   Total CVD

1.07 (0.98-1.16)

1.09 (0.99-1.19)

   Ischemic heart disease

1.16 (1.03-1.29)

1.21 (1.05-1.38)

   Stroke

1.05 (0.93-1.18)

1.11 (0.94-1.30)

   Other CVD

0.89 (0.78-1.02)

0.87 (0.76-1.01)

  1. Abbreviations: CVD, cardiovascular disease; non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
  2. a Age was the time scale in the Cox proportional hazard regression analyses. Relative risks (hazard ratios) and their 95% CIs were adjusted for sex, race/ethnicity, education attainment, diabetes duration, body mass index, leisure-time physical activity, smoking status, alcohol consumption, systolic blood pressure, serum HDL-C concentration, glomerular filtration rate, C-reactive protein, glycated hemoglobin A1C, and self-reported use of prescribed medicine to lower blood cholesterol.
  3. N = 366 adults who attended the morning session of a Mobile Examination Center, had fasted at least 8 hours, and had a valid LDL-C value.