From: Adverse effect profile of trichlormethiazide: a retrospective observational study
 | TCM users (1 mg/day) with matched controls | |||
---|---|---|---|---|
Laboratory Test | Users (N = 99) | Controls (N = 99) | ||
 | Mean ± SE | (95% CI) | Mean ± SE | (95% CI) |
Urea nitrogen, mmol/L | Â | Â | Â | Â |
   Baseline | 5.83 ± 0.18 | (5.47, 6.20) | 5.54 ± 0.18 | (5.18, 5.90) |
   Exposure | 6.10 ± 0.20 | (5.72, 6.51) | 5.53 ± 0.17 | (5.19, 5.87) |
Creatinine, μmol/L |  |  |  |  |
   Baseline | 71.7 ± 1.9 | (67.8, 75.6) | 66.3 ± 2.2 | (61.9, 70.7) |
   Exposure | 73.2 ± 2.3 | (68.6, 77.8) | 67.9 ± 2.5 | (62.9, 72.9) |
Uric acid, μmol/L |  |  |  |  |
   Baseline | 337.4 ± 8.9 | (319.7, 355.1) | 316.0 ± 8.1 | (300.0, 332.0) |
   Exposure | 349.6 ± 8.5 | (332.7, 366.4) | 316.8 ± 7.8 | (301.3, 332.2) |
Sodium, mmol/L | Â | Â | Â | Â |
   Baseline | 142.0 ± 0.3 | (141.5, 142.5) | 141.8 ± 0.2 | (141.3, 142.2) |
   Exposure | 141.1 ± 0.3* | (140.5, 141.7) | 141.4 ± 0.3 | (140.8, 141.9) |
Potassium, mmol/L | Â | Â | Â | Â |
   Baseline | 4.24 ± 0.04 | (4.17, 4.32) | 4.28 ± 0.04 | (4.20, 4.35) |
   Exposure | 4.28 ± 0.04 | (4.20, 4.36) | 4.31 ± 0.04 | (4.23, 4.39) |
 | TCM users (2 mg/day) with matched controls | |||
Laboratory Test | Users (N = 61) | Controls (N = 61) | ||
 | Mean ± SE | (95% CI) | Mean ± SE | (95% CI) |
Urea nitrogen, mmol/L | Â | Â | Â | Â |
   Baseline | 6.15 ± 0.24 | (5.68, 6.62) | 5.66 ± 0.21 | (5.24, 6.09) |
   Exposure | 6.80 ± 0.27 | (6.25, 7.34) | 5.85 ± 0.22 | (5.41, 6.29) |
Creatinine, μmol/L |  |  |  |  |
   Baseline | 73.4 ± 3.1 | (67.2, 79.6) | 68.1 ± 2.2 | (63.7, 72.5) |
   Exposure | 77.7 ± 3.5 | (70.7, 84.7) | 70.3 ± 2.6 | (65.1, 75.7) |
Uric acid, μmol/L |  |  |  |  |
   Baseline | 333.7 ± 11.1 | (311.5, 355.8) | 310.6 ± 9.3 | (291.9, 329.1) |
   Exposure | 381.8 ± 11.0** | (359.7, 403.9) | 327.0 ± 12.0 | (303.0, 351.1) |
Sodium, mmol/L | Â | Â | Â | Â |
   Baseline | 141.8 ± 0.3 | (141.2, 142.3) | 141.9 ± 0.3 | (141.2, 142.5) |
   Exposure | 141.6 ± 0.3 | (141.0, 142.3) | 141.6 ± 0.3 | (141.0, 142.2) |
Potassium, mmol/L | Â | Â | Â | Â |
   Baseline | 4.27 ± 0.06 | (4.16, 4.39) | 4.32 ± 0.06 | (4.21, 4.44) |
   Exposure | 4.13 ± 0.05 | (4.03, 4.23) | 4.36 ± 0.05 | (4.27, 4.45) |