Skip to main content

Table 2 Summary of serum chemical data

From: Adverse effect profile of trichlormethiazide: a retrospective observational study

 

TCM users (1 mg/day) with matched controls

Laboratory Test

Users (N = 99)

Controls (N = 99)

 

Mean ± SE

(95% CI)

Mean ± SE

(95% CI)

Urea nitrogen, mmol/L

    

   Baseline

5.83 ± 0.18

(5.47, 6.20)

5.54 ± 0.18

(5.18, 5.90)

   Exposure

6.10 ± 0.20

(5.72, 6.51)

5.53 ± 0.17

(5.19, 5.87)

Creatinine, μmol/L

    

   Baseline

71.7 ± 1.9

(67.8, 75.6)

66.3 ± 2.2

(61.9, 70.7)

   Exposure

73.2 ± 2.3

(68.6, 77.8)

67.9 ± 2.5

(62.9, 72.9)

Uric acid, μmol/L

    

   Baseline

337.4 ± 8.9

(319.7, 355.1)

316.0 ± 8.1

(300.0, 332.0)

   Exposure

349.6 ± 8.5

(332.7, 366.4)

316.8 ± 7.8

(301.3, 332.2)

Sodium, mmol/L

    

   Baseline

142.0 ± 0.3

(141.5, 142.5)

141.8 ± 0.2

(141.3, 142.2)

   Exposure

141.1 ± 0.3*

(140.5, 141.7)

141.4 ± 0.3

(140.8, 141.9)

Potassium, mmol/L

    

   Baseline

4.24 ± 0.04

(4.17, 4.32)

4.28 ± 0.04

(4.20, 4.35)

   Exposure

4.28 ± 0.04

(4.20, 4.36)

4.31 ± 0.04

(4.23, 4.39)

 

TCM users (2 mg/day) with matched controls

Laboratory Test

Users (N = 61)

Controls (N = 61)

 

Mean ± SE

(95% CI)

Mean ± SE

(95% CI)

Urea nitrogen, mmol/L

    

   Baseline

6.15 ± 0.24

(5.68, 6.62)

5.66 ± 0.21

(5.24, 6.09)

   Exposure

6.80 ± 0.27

(6.25, 7.34)

5.85 ± 0.22

(5.41, 6.29)

Creatinine, μmol/L

    

   Baseline

73.4 ± 3.1

(67.2, 79.6)

68.1 ± 2.2

(63.7, 72.5)

   Exposure

77.7 ± 3.5

(70.7, 84.7)

70.3 ± 2.6

(65.1, 75.7)

Uric acid, μmol/L

    

   Baseline

333.7 ± 11.1

(311.5, 355.8)

310.6 ± 9.3

(291.9, 329.1)

   Exposure

381.8 ± 11.0**

(359.7, 403.9)

327.0 ± 12.0

(303.0, 351.1)

Sodium, mmol/L

    

   Baseline

141.8 ± 0.3

(141.2, 142.3)

141.9 ± 0.3

(141.2, 142.5)

   Exposure

141.6 ± 0.3

(141.0, 142.3)

141.6 ± 0.3

(141.0, 142.2)

Potassium, mmol/L

    

   Baseline

4.27 ± 0.06

(4.16, 4.39)

4.32 ± 0.06

(4.21, 4.44)

   Exposure

4.13 ± 0.05

(4.03, 4.23)

4.36 ± 0.05

(4.27, 4.45)

  1. *P < 0.05 vs. baseline. **P < 0.01 vs. baseline. Abbreviations: TCM, trichlormethiazide; SE, standard error; CI, confidence interval.