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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy

Figure 3

TSN protected the cardiomyocytes ultrastructure against the damage induced by diabetes. Electron micrographs of control hearts (A) showed regular myofibrillar organization with evident Z-lines (white arrow) and normal mitochontria profiles (yellow arrow). In STZ-diabetic hearts (B) and HOE140 pretreatment hearts (D), great size mitochondria with the destruction of cristae were detectable. The ultrastructural appearance of the TSN-treated hearts were similar to controls (C), indicating that the protective effect on the myocardium preserves the ultrastructure of cardiomyocytes. Scale bars, 0.5 μm.

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Cardiovascular Diabetology

ISSN: 1475-2840