| SHR (n = 9) | RD-SHR (n = 7) | STZ-SHR (n = 9) | RD-STZ-SHR (n = 5) | P (Denervation) | P (Diabetes) | P (Interaction) |
---|---|---|---|---|---|---|---|
Initial weight (g) | 258 ± 14 | 267 ± 29 | 269 ± 13 | 272 ± 28 | 0.452 | 0.278 | 0.729 |
Weight 45 days after STZ injection (g) | 310 ± 28 | 322 ± 35 | 275 ± 53* | 223 ± 71# | 0.249 | <0.001 | 0.068 |
Initial plasma glucose (mg/dl) | 84.4 ± 7 | 91.2 ± 5 | 414.1 ± 135* | 357.4 ± 124# | 0.463 | <0.001 | 0.352 |
Plasma glucose 45 days after STZ injection (mg/dl) | 92.0 ± 14 | 91.1 ± 9 | 417.5 ± 114* | 388.0 ± 48# | 0.548 | <0.001 | 0.571 |
Diuresis (mL/24 h) | 11.2 ± 4 | 20.7 ± 7 | 96.9 ± 42* | 103.3 ± 38# | 0.398 | <0.001 | 0.872 |
24-h urinary glucose (mg/24 h) | 0.37 ± 0.4 | 0.23 ± 0.4 | 758.0 ± 544* | 1019.0 ± 379# | 0.236 | <0.001 | 0.235 |
24-h urinary sodium (mEq/24 h) | 1.03 ± 0.3 | 1.29 ± 0.8 | 4.38 ± 2.1* | 4.50 ± 1.8# | 0.680 | <0.001 | 0.881 |
24-h urinary albumin (mg) | 152 [111-341] | 711* [273-1304] | 2456* [1491-3982] | 1538# [667-2988] | 0.472 | <0.001 | <0.001 |