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Table 1 General characteristics of animals studied

From: Renal denervation in an animal model of diabetes and hypertension: Impact on the autonomic nervous system and nephropathy

 

SHR (n = 9)

RD-SHR (n = 7)

STZ-SHR (n = 9)

RD-STZ-SHR (n = 5)

P (Denervation)

P (Diabetes)

P (Interaction)

Initial weight (g)

258 ± 14

267 ± 29

269 ± 13

272 ± 28

0.452

0.278

0.729

Weight 45 days after STZ injection (g)

310 ± 28

322 ± 35

275 ± 53*

223 ± 71#

0.249

<0.001

0.068

Initial plasma glucose (mg/dl)

84.4 ± 7

91.2 ± 5

414.1 ± 135*

357.4 ± 124#

0.463

<0.001

0.352

Plasma glucose 45 days after STZ injection (mg/dl)

92.0 ± 14

91.1 ± 9

417.5 ± 114*

388.0 ± 48#

0.548

<0.001

0.571

Diuresis (mL/24 h)

11.2 ± 4

20.7 ± 7

96.9 ± 42*

103.3 ± 38#

0.398

<0.001

0.872

24-h urinary glucose (mg/24 h)

0.37 ± 0.4

0.23 ± 0.4

758.0 ± 544*

1019.0 ± 379#

0.236

<0.001

0.235

24-h urinary sodium (mEq/24 h)

1.03 ± 0.3

1.29 ± 0.8

4.38 ± 2.1*

4.50 ± 1.8#

0.680

<0.001

0.881

24-h urinary albumin (mg)

152 [111-341]

711* [273-1304]

2456* [1491-3982]

1538# [667-2988]

0.472

<0.001

<0.001

  1. Data are shown as mean ± SEM. SHR: spontaneously hypertensive rats; RD-SHR: renal-denervated spontaneously hypertensive rats; STZ-SHR: diabetic spontaneously hypertensive rats; RD-STZ-SHR: diabetic renal-denervated spontaneously hypertensive rats; n = indicates the number of animals. *P < 0.001 vs. H; #P < 0.01 vs. HRD; (Two-way ANOVA; post hoc: Student Newman Keuls). For the variables diuresis, urinary glucose, and urinary sodium the n is 9, 10, 11 and 11, respectively.