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Table 1 Non-parametric Linkage Analysis of Various Phenotypes of the 200 Italian Families by Merlin software.

From: Proteasome modulator 9 and macrovascular pathology of T2D

Phenotype Prevalence Families Lod Score P-value Empirical P-value
CAD 28.20% 15 1.39 0.006 0.005
Stroke 14.80% 5 1.04 0.014 0.002
Vasculopathy 53.80% 48 0.64 0.040 0.053
Macrovascular Pathology 70.10% 78 2.21 0.0007 0.002
  1. Prevalence = phenotype prevalence among the family subjects studied; Families = families number analyzed; Lod score = derived from the non-parametric linkage analysis by Merlin; Empirical P-value = derived from 1000 replicates by using the gene dropping method; CAD = coronary artery disease; Vasculopathy = based on the presence of plaques and/or angioplasty of carotid arteries, coronary arteries, lower extremities arteries; Macrovascular Pathology = based on the presence of CAD and/or Stroke/TIA and/or Vasculopathy.