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Table 1 Non-parametric Linkage Analysis of Various Phenotypes of the 200 Italian Families by Merlin software.

From: Proteasome modulator 9 and macrovascular pathology of T2D

Phenotype

Prevalence

Families

Lod Score

P-value

Empirical P-value

CAD

28.20%

15

1.39

0.006

0.005

Stroke

14.80%

5

1.04

0.014

0.002

Vasculopathy

53.80%

48

0.64

0.040

0.053

Macrovascular Pathology

70.10%

78

2.21

0.0007

0.002

  1. Prevalence = phenotype prevalence among the family subjects studied; Families = families number analyzed; Lod score = derived from the non-parametric linkage analysis by Merlin; Empirical P-value = derived from 1000 replicates by using the gene dropping method; CAD = coronary artery disease; Vasculopathy = based on the presence of plaques and/or angioplasty of carotid arteries, coronary arteries, lower extremities arteries; Macrovascular Pathology = based on the presence of CAD and/or Stroke/TIA and/or Vasculopathy.