A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals

Table 3 Genotypic and allelic distribution of MTNR1B polymorphisms and association with type 2 diabetes

SNP	Alleles Major/minor	MAF	Genotype Frequency T2DM cases/controls	OR_add (95%CI) ^a	P value*	OR_dom (95%CI)^b	P value*	OR_rec (95%CI) ^c	P value*
rs10830963	C/G	0.40	0.361/0.481/0.159	0.92	0.22	0.85	0.08	1.01	0.96
			0.348/0.508/0.144	(0.81-1.05)		(0.70-1.02)		(0.78-1.30)
rs3781637	A/G	0.14	0.717/0.260/0.022	1.22	0.038	1.17	0.13	2.81	0.01
			0.736/0.252/0.012	(1.01-1.46)		(0.96-1.43)		(1.28-6.17)
rs1562444	A/G	0.31	0.472/0.432/0.096	1.06	0.42	1.02	0.83	1.27	0.14
			0.457/0.456/0.088	(0.92-1.22)		(0.85-1.22)		(0.92-1.74)

^a Calculated using logistic regression, assuming an additive model adjusted for age, sex and BMI
^b Calculated using logistic regression, assuming a dominant model adjusted for age, sex and BMI
^c Calculated using logistic regression, assuming a recessive model adjusted for age, sex and BMI
* P values shown are not corrected for multiple comparisons
MAF: minor allele frequency in control samples; T2DM: type 2 diabetes.

ISSN: 1475-2840