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Table 3 Genotypic and allelic distribution of MTNR1B polymorphisms and association with type 2 diabetes

From: A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals

SNP Alleles
Major/minor
MAF Genotype Frequency
T2DM cases/controls
ORadd
(95%CI) a
P value* ORdom
(95%CI)b
P value* ORrec
(95%CI) c
P value*
rs10830963 C/G 0.40 0.361/0.481/0.159 0.92 0.22 0.85 0.08 1.01 0.96
    0.348/0.508/0.144 (0.81-1.05)   (0.70-1.02)   (0.78-1.30)  
rs3781637 A/G 0.14 0.717/0.260/0.022 1.22 0.038 1.17 0.13 2.81 0.01
    0.736/0.252/0.012 (1.01-1.46)   (0.96-1.43)   (1.28-6.17)  
rs1562444 A/G 0.31 0.472/0.432/0.096 1.06 0.42 1.02 0.83 1.27 0.14
    0.457/0.456/0.088 (0.92-1.22)   (0.85-1.22)   (0.92-1.74)  
  1. a Calculated using logistic regression, assuming an additive model adjusted for age, sex and BMI
  2. b Calculated using logistic regression, assuming a dominant model adjusted for age, sex and BMI
  3. c Calculated using logistic regression, assuming a recessive model adjusted for age, sex and BMI
  4. * P values shown are not corrected for multiple comparisons
  5. MAF: minor allele frequency in control samples; T2DM: type 2 diabetes.