Association of plasminogen activator inhibitor-1 and tissue plasminogen activator with type 2 diabetes and metabolic syndrome in Malaysian subjects

Table 3 Association of fibrinolytic PAI-1 and tPA with metabolic syndrome parameters among normal subjects (n = 131)

Metabolic syndrome Parameters	PAI-1 activity b (P-value)	PAI-1 antigen b (P-value)	tPA activity b (P-value)	tPA antigen b (P-value)
Body Mass Index (kg/m2)	1.199 *(0.001)*	1.079 (0.199)	-1.109 (0.104)	-1.021 (0.783)
Waist circumference (cm)	1.159 *(2.2 × 10*^-4)	1.057 (0.213)	-1.033 (0.496)	-1.035 (0.543)
Diastolic Blood Pressure (mmHg)	-1.038 (0.342)	-1.014 (0.763)	1.064 (0.185)	1.028 (0.607)
Systolic Blood Pressure (mmHg)	-1.009 (0.846)	1.007 (0.889)	1.074 (0.198)	1.084 (0.195)
Triglyceride (mmol/l)	1.119 (0.165)	-1.012 (0.899)	1.064 (0.558)	1.127 (0.331)
HDL- cholesterol (mmol/l)	-1.125 *(0.005)*	-1.067 (0.166)	-1.076 (0.174)	-1.016 (0.807)
Fasting Blood Sugar (mmol/l)	1.047 (0.092)	1.079 *(0.02)*	-1.079 *(0.028)*	1.023 (0.583)
Insulin (pmol/l)	1.941 *(1.2 × 10*^-4)	1.614 *(0.015)*	-1.236- (0.312)	1.288 (0.298)
Insulin Sensitivity (%)	-1.963 *(1.1 × 10*^-4)	-1.637 *(0.012)*	1.265 (0.266)	-1.294 (0.289)
Insulin Resistance	1.393 *(2.2 × 10*^-4)	1.318 *(0.007)*	-1.119 (0.305)	1.135 (0.313)

Result presented as b (P-value) assessed by linear regression, adjusted for age, gender and race. Bolt values are significant. b: coefficient for the relationship between the dependent variable "metabolic syndrome parameters" and the independent variable "fibrinolytic PAI-1 and tPA parameters". The positive sign of the coefficient implies a direct relationship, and the negative sing implies an inverse relationship.

ISSN: 1475-2840