Table 5 Association between the DDAH1 gene polymorphism and plasma ADMA levels, L-arginine levels and L-arginine/ADMA ratio
SNP ID | Genotype | ADMA μmol/l mean (95% CI) | L-arginine μmol/l mean (95% CI) | L-arginine/ADMA mean (95% CI) |
|---|---|---|---|---|
rs233112 | Â | Â | Â | Â |
| Â | AA | 0.45 (0.43-0.46)* | 95.8 (91.7-99.9) | 222.5 (212.0-233.0) |
| Â | AG | 0.45 (0.44-0.46) | 92.4 (89.2-95.5) | 210.7 (202.9-218.5) |
| Â | GG | 0.47 (0.46-0.49) | 95.1 (91.7-96.2) | 209.3 (208.5-219.6) |
rs1498374 | Â | Â | Â | Â |
| Â | GG | 0.45 (0.44-0.46)* | 93.8 (91.1-96.5) | 216.2 (209.5-222.9) |
| Â | GA | 0.46 (0.45-0.47) | 94.0 (89.8-98.2) | 210.5 (200.0-220.9) |
| Â | AA | 0.51 (0.46-0.57) | 94.7 (81.5-107.9) | 214.0 (208.4-219.5) |
rs1498373 | Â | Â | Â | Â |
| Â | CC | 0.44 (0.43-0.45) *** | 94.0 (90.6-97.3) | 219.5 (211.0-227.9) |
| Â | CT | 0.46 (0.45-0.47) | 93.3 (90.0-96.5) | 210.4 (202.2-218.7) |
| Â | TT | 0.49 (0.46-0.52) | 96.8 (89.2-104.5) | 204.0 (187.7-219.6) |
rs1241321 | Â | Â | Â | Â |
| Â | GG | 0.45 (0.43-0.47) | 94.8 (88.5-101.0) | 220.1(203.5-236.6) |
| Â | GA | 0.45 (0.44-0.46) | 94.2 (90.9-97.5) | 215.1 (207.0-223.2) |
| Â | AA | 0.46 (0.45-0.47) | 93.1 (89.7-96.6) | 210.3 (201.8-218.8) |
rs1403956 | Â | Â | Â | Â |
| Â | GG | 0.45 (0.44-0.46)* | 98.0 (91.1-96.9) | 217.6 (210.2-224.9) |
| Â | GA | 0.46 (0.45-0.47) | 93.2 (89.4-96.9) | 209.4 (200.3-218.5 ) |
| Â | AA | 0.49 (0.46-0.52) | 98.7 (88.4-109.1) | 203.3 (182.1-224.6) |
rs587843 | Â | Â | Â | Â |
| Â | CC | 0.46 (0.44-0.48) | 92.3 (86.5-98.0) | 207.7 (193.6-221.7) |
| Â | CG | 0.45 (0.44-0.46) | 94.3 (91.2-97.2) | 216.7 (209.3-224.3) |
| Â | GG | 0.46 (0.45-0.47) | 94.2 (90.2-98.3) | 212.8 (202.7-223.0) |