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Table 4 Clinical characteristics of subjects with rs1241321 AA genotype and GG + AG genotypes

From: The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study

  AA n = 314 GG + AG n = 500 P value
Age (years) 64.3 ± 10.2 65.5 ± 10.2 0.13
Gender (Women/men) 77/237 120/380 0.87
BMI (Kg/m2) 26.2 ± 3.8 26.2 ± 3.5 0.98
Diabetes (%) 100 (31.4) 209 (41.8) 0.004
Hypertension (%) 233 (74.2) 367 (73.4) 0.80
Smoking (%) 67 (21.3) 103 (20.6) 0.80
Hypercholesterolemia (%) 155 (49.4) 212 (42.4) 0.05
Cholesterol (mg/dl)    
Total 171.2 ± 35.2 171.2 ± 36.9 0.99
HDL-Cholesterol 43.7 ± 12.3 43.1 ± 12.2 0.49
LDL-Cholesterol 105.5 ± 31.1 106.1 ± 32.7 0.80
Triglyceride (mg/dl) 146.4 ± 88.3 149.8 ± 92.4 0.61
Creatinine (mg/dl) 1.2 ± 0.7 1.2 ± 0.9 0.79
eGFR (ml/min per 1.73 m2) 78.0 ± 27.2 75.6 ± 27.3 0.22
Fasting blood sugar(mg/dl) 105.8 ± 35.4 111.7 ± 40.0 0.03
ADMA (μmol/l) 0.46 ± 0.10 0.45 ± 0.10 0.66
L-arginine (μmol/l) 93.1 ± 30.9 94.4 ± 33.0 0.60
L-arginine/ADMA 210.3 ± 76.6 216.3 ± 82.9 0.30
Medications    
   Anti-platelet drug 269 (85.7) 423 (84.6) 0.68
   Statins 129 (41.1) 216 (43.2) 0.55
   ACE-Inhibitor/ARB 83 (26.4) 136 (27.2) 0.81
   Calcium channel blocker 65 (20.7) 119(23.8) 0.30
   Hypoglycemic treatments    
Insulin (%) 19 (6.1) 40 (8.0) 0.30
OHA (%) 81 (25.8) 163 (32.6) 0.04
Insulin + OHA (%) 2 (0.6) 6 (1.2) 0.43
  1. ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker. BMI: body mass index; eGFR: estimated glomerular filtration rate; OHA: oral hypoglycemic agents.