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Table 4 Clinical characteristics of subjects with rs1241321 AA genotype and GG + AG genotypes

From: The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study

 

AA n = 314

GG + AG n = 500

P value

Age (years)

64.3 ± 10.2

65.5 ± 10.2

0.13

Gender (Women/men)

77/237

120/380

0.87

BMI (Kg/m2)

26.2 ± 3.8

26.2 ± 3.5

0.98

Diabetes (%)

100 (31.4)

209 (41.8)

0.004

Hypertension (%)

233 (74.2)

367 (73.4)

0.80

Smoking (%)

67 (21.3)

103 (20.6)

0.80

Hypercholesterolemia (%)

155 (49.4)

212 (42.4)

0.05

Cholesterol (mg/dl)

   

Total

171.2 ± 35.2

171.2 ± 36.9

0.99

HDL-Cholesterol

43.7 ± 12.3

43.1 ± 12.2

0.49

LDL-Cholesterol

105.5 ± 31.1

106.1 ± 32.7

0.80

Triglyceride (mg/dl)

146.4 ± 88.3

149.8 ± 92.4

0.61

Creatinine (mg/dl)

1.2 ± 0.7

1.2 ± 0.9

0.79

eGFR (ml/min per 1.73 m2)

78.0 ± 27.2

75.6 ± 27.3

0.22

Fasting blood sugar(mg/dl)

105.8 ± 35.4

111.7 ± 40.0

0.03

ADMA (μmol/l)

0.46 ± 0.10

0.45 ± 0.10

0.66

L-arginine (μmol/l)

93.1 ± 30.9

94.4 ± 33.0

0.60

L-arginine/ADMA

210.3 ± 76.6

216.3 ± 82.9

0.30

Medications

   

   Anti-platelet drug

269 (85.7)

423 (84.6)

0.68

   Statins

129 (41.1)

216 (43.2)

0.55

   ACE-Inhibitor/ARB

83 (26.4)

136 (27.2)

0.81

   Calcium channel blocker

65 (20.7)

119(23.8)

0.30

   Hypoglycemic treatments

   

Insulin (%)

19 (6.1)

40 (8.0)

0.30

OHA (%)

81 (25.8)

163 (32.6)

0.04

Insulin + OHA (%)

2 (0.6)

6 (1.2)

0.43

  1. ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker. BMI: body mass index; eGFR: estimated glomerular filtration rate; OHA: oral hypoglycemic agents.