Table 2 Physiological parameters determined in rats 3 weeks following injection of pcDNA3.1 vector or pcDNA-CYP2J3(+)
From: CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats
| Â | Treatment Group | ||||
|---|---|---|---|---|---|
| Â | Normal Water-treated | Fructose-treated | |||
Variable | Normal | Fructose | Fructose+L-NMMA | Fructose+ pcDNA-CYP2J3(+) | Fructose+ pcDNA-CYP2J3(+)+L-NMMA |
Glucose (mmol/L) | 4.56 ± 0.68 | 5.04 ± 0.62 | 6.43 ± 1.09 | 5.84 ± 0.42 | 6.55 ± 0.84 |
Insulin (mIU/L) | 9.65 ± 0.83 | 23.84 ± 1.37* | 25.41 ± 3.25 | 6.24 ± 0.33# | 22.54 ± 0.99** |
HOMA-IR | 1.85 ± 0.32 | 5.34 ± 0.38* | 7.26 ± 0.56 | 1.62 ± 0.42# | 6.56 ± 0.28** |
Triglyceride (mmol/L) | 0.56 ± 0.32 | 1.23 ± 0.17* | 1.06 ± 0.17 | 1.19 ± 0.24# | 1.14 ± 0.28 |
Urine osmolarity (mOsml/Kg H2O) | 857 ± 101 | 377.4 ± 69.95* | 346.14 ± 34.24 | 763 ± 54.49# | 258 ± 48.68** |
Body weight (g) | 273 ± 30 | 356 ± 29.3 | 347 ± 35 | 332 ± 19.7 | 379 ± 20 |