Skip to main content

Table 2 Physiological parameters determined in rats 3 weeks following injection of pcDNA3.1 vector or pcDNA-CYP2J3(+)

From: CYP2J3 Gene Delivery Reduces Insulin Resistance via Upregulation of eNOS in Fructose-treated Rats

  Treatment Group
  Normal Water-treated Fructose-treated
Variable Normal Fructose Fructose+L-NMMA Fructose+ pcDNA-CYP2J3(+) Fructose+ pcDNA-CYP2J3(+)+L-NMMA
Glucose (mmol/L) 4.56 ± 0.68 5.04 ± 0.62 6.43 ± 1.09 5.84 ± 0.42 6.55 ± 0.84
Insulin (mIU/L) 9.65 ± 0.83 23.84 ± 1.37* 25.41 ± 3.25 6.24 ± 0.33# 22.54 ± 0.99**
HOMA-IR 1.85 ± 0.32 5.34 ± 0.38* 7.26 ± 0.56 1.62 ± 0.42# 6.56 ± 0.28**
Triglyceride (mmol/L) 0.56 ± 0.32 1.23 ± 0.17* 1.06 ± 0.17 1.19 ± 0.24# 1.14 ± 0.28
Urine osmolarity (mOsml/Kg H2O) 857 ± 101 377.4 ± 69.95* 346.14 ± 34.24 763 ± 54.49# 258 ± 48.68**
Body weight (g) 273 ± 30 356 ± 29.3 347 ± 35 332 ± 19.7 379 ± 20
  1. Values shown are mean ± SEM. *P < 0.05 vs. Normal group; #P < 0.05 vs. Fructose group; **P < 0.05 vs. Fructose+ pcDNA-CYP2J3(+) group.