Effects of CYP2J3 gene delivery on activation of rat insulin receptor signaling and AMPK phosphorylation. Levels of, PI3K and P-AKT in liver (A) and muscle (B), and P-AMPK in liver and muscle (C) were assessed by western blot at week 6 of the study. Representative western blot of protein above and corresponding densitometric quantification of three experiments are shown. Values shown are mean ± SEM. *P < 0.05 vs. Normal group; #P < 0.05 vs. Fructose group; **P < 0.05 vs. Fructose+ pcDNA-CYP2J3(+) group.