Effects of L-NMMA on fructose-induced hypertension with CYP2J3 gene delivery in rats. The elevation of systolic blood pressure observed in fructose-treated rats was decreased 1, 2 and 3 weeks after injection of CYP2J3(+) (at weeks 4, 5 and 6 of the study). Administration of L-NMMA significantly increased blood pressure in rats of Fructose group. Interestingly, administration of L-NMMA significantly increased blood pressure in rats of Fructose+pcDNA-2J3(+) group. Values shown are mean ± SEM from each group of rats, respectively.*P < 0.05 compared to rats treated without fructose, #P < 0.05 compared to rats treated with fructose, **P < 0.05 compared to rats in Fructose + pcDNA-CYP2J3(+) group; n = 4 to 10 per group per time point.