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Table 4 HOMA-IR and the risk for new cardiovascular events (vascular death, myocardial infarction or stroke) in patients with manifest arterial disease (n = 2611)

From: Insulin resistance increases the occurrence of new cardiovascular events in patients with manifest arterial disease without known diabetes. The SMART study

HOMA-IR   tertile 1 tertile 2 tertile 3
  Model # events HR (95%CI) # events HR (95%CI) # events HR (95%CI)
All vascular events 1 26 1 (reference) 52 1.86 (1.16-2.98) 48 1.70 (1.05-2.74)
  2   1 (reference)   1.92 (1.20-3.08)   1.78 (1.10-2.89)
  3   1 (reference)   1.86 (1.16-3.00)   1.79 (1.10-2.90)
  4   1 (reference)   1.80 (1.10-2.96)   1.50 (0.85-2.68)
Myocardial infarction 1 17 1 (reference) 30 1.63 (0.90-2.96) 27 1.42 (0.77-2.61)
  2   1 (reference)   1.61 (0.89-2.93)   1.41 (0.76-2.61)
  3   1 (reference)   1.57 (0.86-2.85)   1.39 (0.75-2.59)
  4   1 (reference)   1.34 (0.72-2.51)   0.95 (0.46-1.98)
All cause mortality 1 20 1 (reference) 39 1.69 (0.99-2.91) 32 1.43 (0.82-2.51)
  2   1 (reference)   1.80 (1.05-3.10)   1.56 (0.88-2.75)
  3   1 (reference)   1.76 (1.02-3.03)   1.63 (0.92-2.88)
  4   1 (reference)   1.83 (1.04-3.24)   1.56 (0.78-3.09)
Vascular mortality 1 9 1 (reference) 23 2.26 (1.04-4.88) 15 1.50 (0.66-3.43)
  2   1 (reference)   2.42 (1.12-5.25)   1.72 (0.74-3.98)
  3   1 (reference)   2.24 (1.03-4.88)   1.74 (0.75-4.04)
  4   1 (reference)   2.56 (1.15-5.70)   1.85 (0.73-4.73)
  1. Model 1: adjusted for age and gender
  2. Model 2: model I additionally adjusted for current smoking, lipid lowering medication, blood pressure-lowering medication
  3. Model 3: model II additionally adjusted for history of coronary artery disease, cerebrovascular disease, abdominal aortic aneurysm and peripheral arterial disease.
  4. Model 4: model II additionally adjusted for waist circumference, systolic blood pressure, triglycerides, HDL-c, glucose and hs-CRP