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Table 2 Characteristics of diabetic patients with asymptomatic CAD and without CAD.

From: Silent coronary artery disease in type 2 diabetes mellitus: the role of Lipoprotein(a), homocysteine and apo(a) polymorphism

 

CAD

NO CAD

p-value

Number

75

75

 

Sex (M/F)

62/13

62/13

NS

Age (years)

56.6 ± 6.2

56.7 ± 6.2

NS

Duration of diabetes (years)

7.9 ± 5.7

8.0 ± 4.9

NS

BMI

26.4 ± 3.4

26.1 ± 3.7

NS

HbA1c (%)

7.8 ± 1.4

7.4 ± 1.4

NS

Cholesterol (mmol/l)

   

   Mean

5.6 ± 0.9

5.4 ± 1.0

NS

   Median

5.6

5.2

 

   Range

3.8–9.0

3.4–8.6

 

LDL (mmol/l)

   

   Mean

2.7 ± 1.0

2.5 ± 1.0

NS

   Median

2.8

2.6

 

   Range

1.0–5.9

0.5–6.0

 

HDL (mmol/l)

   

   Mean

1.1 ± 0.2

1.2 ± 0.2

<0.05

   Median

1.1

1.3

 

   Range

0.6–2.0

0.9–2.1

 

Triglycerides (mmol/l)

   

   Mean

1.7 ± 0.6

1.6 ± 0.6

NS

   Median

1.7

1.5

 

   Range

0.8–3.2

0.6–3.7

 

Microalbuminuria (%)

42.7

10.7

<0.0001

AER (mg/day)

   

   Mean

53.0 ± 67.8

22.5 ± 37.5

<0.01

   Median

25.0

10.0

 

   Range

4.5–293.1

4.9–258.3

 

Smokers (%)

57.3

29.3

<0.001

Family history of CAD (%)

36.0

30.7

NS

Hypertension (%)

53.3

57.3

NS

Autonomic neuropathy (%)

29.3

22.7

NS

Lp(a) levels (mg/dl)

   

   Mean

22.0 ± 18.9

16.0 ± 19.4

<0.05

   Median

18.0

7.0

 

   Range

0.5–85

0–88.5

 

Subjects with Lp(a) levels >30 mg/dl (%)

33.3%

17.3%

<0.05

tHcy levels (mmol/l)

   

   Mean

13.6 ± 6.0

11.4 ± 4.9

<0.05

   Median

12.0

10.0

 

   Range

7.4–41.1

5.1–35.6

 

Subjects with tHcy levels >14.0 mmol/l (%)

42.7

26.7

<0.05

Subjects with at least one isoform of low MW (%)

70.7

29.3

<0.0001

  1. LDL = Low Density Lipoprotein; HDL = High Density Lipoprotein; BMI = Body Mass Index; AER = Albumin Excretion Rate. Lp(a) = Lipoprotein(a); tHcy = total homocysteine; Apo(a) = Apolipoprotein(a); CAD = Coronary Artery Disease; tHcy = total homocysteine; MW = Molecular Weight