Skip to main content

Advertisement

Table 2 Atherosclerosis promoting effects of AGEs: Receptor Mediated Mechanisms

From: How hyperglycemia promotes atherosclerosis: molecular mechanisms

Promoting inflammation
   Secretion of cytokines such as TNF-α, IL-1 [74].
   Chemotactic stimulus for monocyte-macrophages [37, 38]
Induction of cellular proliferation
   Stimulation of PDGF [37] and IGF-I [40] secretion from monocytes and possibly SMC.
Endothelial dysfunction
   Increased permeability of EC monolayers [34, 35]
   Increased procoagulant activity [35]
   Increased expression of adhesion molecules [33]
   Increased Intracellular oxidative stress [31, 34]
  1. IGF-I = Insulin-like growth factor I; IL-1 = Interleukin-1; PDGF = Platelet-derived growth factor; TNF-α = Tumor necrosis factor-α.